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phenobarbital will minimize the extent or outcome of flurbiprofen by influencing hepatic enzyme CYP2C9/ten metabolism. Slight/Importance Not known.phenobarbital decreases amounts of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with potent CYP3A4 inducers; these medication minimize expo